2nd Bonn Conference on Mathematical Life Sciences - Programme
12:30 - 14:00
Registration with coffee (Foyer)
14:00 - 14:30
Welcome (Lecture hall 2)
14:30 - 16:00
Keynotes
Session chairs: Jan Hasenauer & Kevin Thurley • Lecture hall 2
14:30 - 15:15
Anna Marciniak-Czochra (Institute for Mathematics, University of Heidelberg, Germany)
Space-scale separation and pattern selection in mechano-chemical models of symmetry breaking
15:15 - 16:00
Ursula Klingmüller (Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany)
Statistical inference of chromatin- and transcription dynamics in living cells
16:00 - 16:30
Coffee break (Foyer)
16:30 - 18:00
Parallel tracks with invited and selected talks
Modelling of Cellular Pathways 1
Session chair: Jan Hasenauer
Lecture hall 7
16:30 - 17:00
Julio Banga (Computational Biology Lab, MBG-CSIC, Pontevedra, Spain)
Climbing the Ladder of Inverse Problems in Computational Systems Biology
17:00 - 17:15
Sophia Dehnen (Physics Department, University of Freiburg, Germany)
- Condition-Specific Profile Likelihood Analysis: Visualizing how Individual Experimental Conditions Shape Parameter Estimates
17:15 - 17:30
Sebastian Persson (The Francis Crick Institute, London, UK)
- PEtab SciML: The missing layer for scalable and flexible scientific machine learning modeling in biology
17:30 - 17:45
Nicole Radde (Institute for Stochastics and Applications, University of Stuttgart, Germany)
- A population model reveals a surprising role of stochastic cell division in epigenetic memory systems
17:45 - 18:00
Yogesh Bali (Johannes Gutenberg University of Mainz, Germany)
- Mechanochemical Energy Landscapes Under Force: Catch–Slip Bonds in T-Cell Activation
Modelling of Endocrine Systems
Session chair: Maren Philipps
Lecture halls 5+6
16:30 - 17:00
Jae Kyoung Kim (Dept. of Mathematical Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea)
From Blackboard to Bedside: Translating Mathematical Sleep Models into Samsung Galaxy Watch
17:00 - 17:15
Belinda Lombard (School of Mathematics, University of Birmingham, UK)
- Regulation of ultradian pulsatility and stress responses in the human HPA axis
17:15 - 17:30
Chloé Weckel (BIOS, PRC, UMR CNRS, Université de Tours, Centre INRAE Val de Loire, Nouzilly & MUSCA, Université Paris-Saclay, Inria Centre Saclay–Île-de-France, Palaiseau, France)
- Spatiotemporal modeling of signaling pathways: impact of endosomal compartmentalization and application to gonadotropin receptors
17:30 - 17:45
Rafael Arutjunjan (Institute of Physics, University of Freiburg, Germany)
- Adapting Confidence Thresholds and Profile Likelihood Analysis to Small Sample Sizes
17:45 - 18:00
Celvic Coomber (Explainable AI for Biology, Zuse Institute Berlin & Technische Universität Berlin, Germany)
- Investigating endogenous opioids unravels the mechanisms behind opioid induced constipation, a mathematical modeling approach
Mathematical Biology 1
Session chair: Juan Velázquez
Lecture halls 3+4
16:30 - 17:00
Marie Doumic-Jauffret (Inria & École Polytechnique, Center for Applied Mathematic, Merge project-team, France)
Mathematical modelling to unravel the link between senescence and telomere length dynamics
17:00 - 17:15
Carola Sophia Heinzel (Department for Mathematical Stochastics, University of Freiburg, Germany)
- Statistical Test to compare the Linkage Model and the Admixture Model based on Central Limit Results
17:15 - 17:30
Saeed Salehi (Biosystems and Bioprocess Engineering Group, Bio2Eng, IIM-CSIC, Vigo, Spain & BioTeC+, Chemical and Biochemical Process Technology and Control, KU Leuven, Ghent, Belgium)
-
Understanding When Lotka–Volterra Models Fail in Microbial Community Analysis
17:30 - 17:45
Alexander Browning (University of Melbourne, Australia)
-
Heterogeneity in temporally fluctuating environments
17:45 - 18:00
Torkel Loman (University of Oxford, UK)
- Parametric and Functional Identifiability for Universal Differential Equations
from 18:00
Welcome reception (Foyer)
8:30 - 9:00
Welcome coffee (Foyer)
9:00 - 10:30
Keynotes
Session chair: Jan Hasenauer • Lecture hall 2
9:00 - 9:45
Bernd Bodenmiller (Department of Quantitative Biomedicine, University of Zurich & Institute for Molecular Health Sciences, ETH Zürich, Switzerland)
Highly multiplexed imaging of tissues with subcellular resolution by imaging mass cytometry
9:45 - 10:30
Helen Byrne (Mathematical Institute, University of Oxford, UK)
Understanding the shape of vascular networks using topological data analysis
10:30 - 11:00
Coffee break (Foyer)
11:00 - 12:30
Parallel tracks with invited and selected talks
Bioinformatics and Biostatistics 1
Session chairs: Lea Seep & Jan Hasenauer
Lecture hall 7
11:00 - 11:30
Xin Lai (Faculty of Medicine and Health Technology, Tampere University, Finland)
- HallmarkGraph: a cancer hallmark informed graph neural network for classifying hierarchical tumor subtypes
11:30 - 11:45
Alina Schenk (Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Germany)
- A regularized Cox model for selecting interactions and time-varying covariate effects
11:45 - 12:00
Oliver Lemke (Institute of Biochemistry, Charité - Universitätsmedizin Berlin, Germany)
- The role of metabolism in shaping enzyme structures over 400 million years of evolution
12:00 - 12:15
Franziska Kimmig (Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Germany)
- Molecular signatures of post-acute sequelae of COVID-19
12:15 - 12:30
Roy Gusinow (Life & Medical Sciences-Institut (LIMES) & Bonn Center for Mathematical Life Science, University of Bonn, Germany)
- Federated Latent Transition Models for Post-Acute Infection Syndromes
Tumor Microenvironment 1
Session chair: Kevin Thurley
Lecture halls 5+6
11:00 - 11:30
Nils Blüthgen (Institute for Theoretical Biology, Charité – Universitätsmedizin Berlin & Humboldt-Universität zu Berlin, Germany)
Modeling latent variables in pooled single cell screens unveils clinically relevant transcriptional modules induced by oncogenes
11:30 - 11:45
Lara Schmalenstroer (Bioinformatics & Computational Biophysics, University of Duisburg-Essen, Germany)
- Mathematical Modeling of Persistent Treatment Responses After Targeted Radiotherapy in Cancer
11:45 - 12:00
Luke De Bretton-Gordon (Mathematical Institute, University of Oxford, UK)
- An Interdisciplinary Approach to Quantifying the Impact of T-Cell Exhaustion on the Tumour Microenvironment
12:00 - 12:15
Madhuri Majumder (The Hebrew University of Jerusalem, The Alexander Silberman Institute of Life Sciences, Israel)
- Modulatory Principles of Cellular Interactions in Hierarchical Cell Organization
12:15 - 12:30
Lukas Kiwitz (Institute of Experimental Oncology, University Hospital Bonn, Germany)
- Quantitative analysis of CODEX multiplexed histological imaging data in the tumour microenvironment
Infectious Disease Modelling 1
Session chair: Martin Kühn
Lecture halls 3+4
11:00 - 11:15
Maylis Layan (Institut Pasteur, Université de Paris, France)
- Impact of the COVID-19 pandemic on the acquisition of ESBL-producing Klebsiella pneumoniae in hospitals: a modelling study on the intensive care unit of Guadeloupe
11:15 - 11:30
Alan Rendall (Institute of Mathematics, Johannes Gutenberg University Mainz, Germany)
- Backward bifurcations and multistationarity
11:30 - 11:45
Julia Bicker (Institute of Software Technology, German Aerospace Center (DLR), Cologne, Germany)
- A hybrid approach for the simulation of spatially-resolved susceptible-infected-recovered epidemics using the method of moments for stochastic reaction networks
11:45 - 12:00
Marvin Schulte (Fraunhofer Institute for Industrial Mathematics ITWM, Division Processes and Materials, Kaiserslautern, Germany)
- The influence of the mutation process on the long-term behavior of infectious diseases
12:00 - 12:15
Burcu Gürbüz (Institute of Mathematics, Johannes Gutenberg University Mainz, Germany)
- Modeling time-dependent vaccine efficacy and re-vaccination dynamics in an extended SIRS framework
12:15 - 12:30
Shrichand Bhuria (Quantitative methods in public health (METIS), École des hautes études en santé publique (EHESP) Rennes, France)
- Modelling the Spread of Healthcare-Associated Infections through a Nationwide Patient-Based Network in France’s Healthcare Settings
12:30 - 13:45
Lunch (University canteen - CAMPO)
13:45 - 15:15
Parallel tracks with invited and selected talks
Modelling of Cellular Pathways 2
Session chair: Daniel Weindl
Lecture hall 7
13:45 - 14:15
Andreas Raue (Department of Applied Computer Science and Medicine, University of Augsburg, Germany)
The Translational Gap in Mechanistic Modeling
14:15 - 14:30
Jenny Geiger (Institute of Cell Biology and Immunology, University of Stuttgart, Germany)
- Stochasticity contributes to explaining heterogeneity in mitochondrial engagement during apoptosis
14:30 - 14:45
Rifaldy Fajar (AI-BioMedicine Research Group, IMCDS-BioMed Research Foundation, Indonesia)
- Mathematical Modeling of Canonical–Noncanonical NF-ΚB Crosstalk Driving Early CD8+ T-Cell Fate Bifurcation and Long-Term Effector–Memory Balance
14:45 - 15:00
Gesina Menz (Department of Information Technology, Uppsala University, Sweden)
- Multi-Framework Modelling of Population-Level Cellular Signalling
15:00 - 15:15
Mio Heinrich (CIBSS Centre for Integrative Biological Signalling Studies & Freiburg Center for Data Analysis and Modeling, University of Freiburg, Germany)
- Flavours of Practical Identifiability: Sensitivities, Confidence, and Confusion
Mathematical Biology 2
Session chair: Kevin Thurley
Lecture halls 5+6
13:45 - 14:00
Hugo Dourado (Heinrich Heine University, Düsseldorf, Germany)
- Growth Mechanics and the oscillatory biomass allocation in self-replicating cells
14:00 - 14:15
Lisa Li (Institute of Experimental Oncology, University Hospital Bonn, Germany)
- Towards data-based mathematical models of spatiotemporal immune-cell interactions
14:15 - 14:30
Gayathri Ramesan (Max Planck Institute
for Neurobiology of Behavior — caesar, Bonn, Germany)
-
Critical dynamics generates slow manifolds for timing in neural networks
14:30 - 14:45
Francis Tetteh Batsa (African Institute for Mathematical Sciences Ghana)
- A Fractional Derivative Approach to Model Anomalous Mass Transport in Atherosclerosis Plaque Formation
14:45 - 15:15
Becca Asquith (Department of Infectious Disease, Imperial College London, UK)
KIRs and T cell dynamics
Infectious Disease Modelling 2
Session chair: Martin Kühn
Lecture halls 3+4
13:45 - 14:00
Nils Gubela (Mathematics of Data Sciences, Freie Universität Berlin, Germany)
- Modelling transient behaviour changes during the 2022 mpox outbreak using temporal adaptive networks
14:00 - 14:15
Alexandra Teslya (University Medical Center Utrecht, Utrecht University, The Netherlands)
- From Classrooms to Communities: Modeling the Impact of School-Based Interventions for Future Pandemic Response
14:15 - 14:30
Fredrick Asenso Wireko (Department of Mathematics, Kwame Nkrumah University of Science and Technology, Ghana)
- Fractional-Order Modelling and Data-Driven Analysis of Lymphatic Filariasis Dynamics in Ghana
14:30 - 14:45
Sydney Paltra (Faculty V - Mechanical Engineering and Transport Systems, Technical University Berlin, Germany)
- Inferring Mobility Reductions from COVID-19 Disease Spread along the Urban-Rural Gradient
14:45 - 15:00
Henrik Zunker (Institute of Software Technology, German Aerospace Center (DLR), Cologne, Germany)
- A semi-continuous Graph-ODE approach with flow-based formulations to avoid quadratic system growth in Lagrangian metapopulation models
15:00 - 15:15
Punya Alahakoon (Pandemic Sciences Institute, University of Oxford, UK)
- Enhancing epidemiological parameter inference using quantitative diagnostic data
15:15 - 16:30
Poster session 1 (odd numbers)
with coffee break (Foyer & seminar room 1-4)
No. 1 Alfredo Acosta - Optimal Theory in Surveillance and Intervention Strategies for African Swine Fever and Highly Pathogenic Avian Influenza (Infectious Disease Modelling)
No. 3 Nissrin Alachkar - Dissecting CD8+ T cell dynamic responses in adoptive T-cell transfer therapy of melanoma (Mathematical Biology)
No. 5 Nelli Blank-Stein - Immune competence alters neurodevelopmental vulnerability to micro- and nanoplastic exposure in human brain organoids (Organoids and Stem Cell Biology)
No. 7 Karla Bonic-Babic - A comparison of three methods for estimating the probability of a major outbreak (Infectious Disease Modelling)
No. 9 Reindorf Borkor - Improved Autism Spectrum Disorder Detection using Machine Learning Methods: An Integration of fMRI and RNA Seq Data (Bioinformatics and Biostatistics)
No. 11 Aleksandr Bryzgalov - Spectral radius–based analytical evaluation of how daily contact rate fluctuations influence infectious disease dynamics (Infectious Disease Modelling)
No. 13 Benjamin Castellaz* - Bridging Model and Data: A Parametrization-and-Projection Method for Overdetermined Stochastic Inverse Problems in Systems Biology (Modelling of Cellular Pathways)
No. 15 Sunhwa Choi - Replacing Markovian Assumptions with Non-Markovian Reality in Epidemic Parameter Estimation (Infectious Disease Modelling)
No. 17 Isabelle Cochrane - Use of a Scattered Light Integrating Collector (SLIC) for Point of Care Testing to detect bacteria in fluid samples from Prosthetic Joint Infections of the lower limb (Infectious Disease Modelling)
No. 19 Monica Veronica Crankson - Optimal control and cost-effectiveness analysis of a two-strain bacterial meningitis epidemic model: Insights for effective public health interventions (Infectious Disease Modelling)
No. 21 Talip Yasir Demirtas - JANUS: Joint ANalysis for augmentation of clUSter specificity (Bioinformatics and Biostatistics)
No. 23 Janne Frenz* - Simulation of ultra-high dose rate (UHDR) irradiations using a Monte Carlo-based dose engine (Tumor Microenvironment)
No. 25 Ransford Ganyo - Modelling the impact of autoimmune hepetatis on liver cirrhosis progression (Infectious Disease Modelling)
No. 27 Carlotta Felicia Gerstein - Modeling spatially heterogeneous infectious disease spread with chances and challenges (Infectious Disease Modelling)
No. 29 Jonas Guzik - Prediction of linear B cell epitopes using outlier detection and in-silico hydrolysis with protein language models (Bioinformatics and Biostatistics)
No. 31 Manuel Haas - Learning Convex Temporal Regularizers for the Inverse Problem in ECGI (Mathematical Biology)
No. 33 Kushal Haldar - Dynamics of multi-team cell fate decision networks (Mathematical Biology)
No. 35 Carolin Kaffiné - Disentangling Familial and Syndromic Facial Features Using Latent Embedding Analysis (Bioinformatics and Biostatistics)
No. 37 Charles M. Kaumbutha - Advancing Explainability in Machine Learning Models for Alzheimer’s Disease Prediction (Bioinformatics and Biostatistics)
No. 39 Sahil Khan - APP-Driven Vaccine Design: A Quantitative Framework for Optimizing Epitope Presentation (Modelling of Cellular Pathways)
No. 41 Agbatan Fiacre Luc Kouderin - A Cascade Framework for Quantifying the Operational Effectiveness of Insecticide-Treated Nets (ITNs) in Benin. (Infectious Disease Modelling)
No. 43 Sophia Krix - Integrative Single-Cell Modeling and TCR Repertoire Profiling Reveal a Sleep-Immune-Brain Axis in Early Alzheimer’s Disease (Single-Cell Analysis)
No. 45 Torkel Loman - Catalyst: Fast and flexible modeling of reaction networks (Modelling of Cellular Pathways)
No. 47 Pascal Lukas - Determining viral spread and innate immune dynamics in human respiratory epithelium (Infectious Disease Modelling)
No. 49 Karola Mai - ConvexGating infers gating strategies from clusters in single cell cytometry data (Single-Cell Analysis)
No. 51 Robin Müller - Model Based Analysis Of The Mutational Landscape In Antibody Affinity Maturation (Mathematical Biology)
No. 53 Barbora Nemcová - Unjustified Poisson assumptions lead to overconfident estimates of the effective reproductive number (Infectious Disease Modelling)
No. 55 Nicholas Opoku - Understanding the Transmission and Spread of Drug Sensitive and Resistant Strains within a Population: A Mathematical Modelling Approach (Infectious Disease Modelling)
No. 57 Matthias Overmann - Benchmarking precision matrix estimation methods for differential co-expression network analysis (Mathematical Biology)
No. 59 Jörg Peter - Incorporating tumor growth models into physical simulation of radiological, nuclear medicine, and optical imaging systems (Tumor Microenvironment)
No. 61 Sneha Pushpa Ramesan - In silico and patient-derived organoid-based therapy recommendations for colon carcinomas (Organoids and Stem Cell Biology)
No. 63 Sandra Rjeschni - Modeling vertical HIV transmission: a comparison with WHO high-risk assessment in the LIFE studies (Infectious Disease Modelling)
No. 65 Annika Rohde - Glucose Uptake Assay to Study Functional Maturation of Intestinal Organoids (Organoids and Stem Cell Biology)
No. 67 Nina Schmid - Universal differential equations for wastewater-based epidemiology (Infectious Disease Modelling)
No. 69 Angela Shaw - The Inhibitome: A Genome-Wide Map of Inhibitory Gene Relationships (Bioinformatics and Biostatistics)
No. 71 Oladimeji Samuel Sowole - Curvature-Weighted Transmission Improves Network Epidemic Prediction and Control (Infectious Disease Modelling)
No. 73 Jasper Spitzer - The AAtlas - Atlas of the Aorta in Health and Disease (Single-Cell Analysis)
No. 75 Jörn Starruß - Morpheus 3.0: Spatial reaction dynamics in deforming cell shapes (Modelling of Cellular Pathways)
No. 77 Christoph Sticha-Kaiser - A General Deterministic Model of Ordinary Differential Equations for a Broad Variety of Different Diseases (Infectious Disease Modelling)
No. 79 Alexandra Teslya - Evaluating the impact and effectiveness of HIV testing strategies among men who have sex with men in the Netherlands (Infectious Disease Modelling)
No. 81 Jan Tietgen - Comparison of discrete modelling methods for biological neural networks (Mathematical Biology)
No. 83 Francis Didier Tshianyi Mwana Kalala - STAT1–p53 Dynamics Program Cell Fate through p21 and PUMA (Modelling of Cellular Pathways)
No. 85 Gemma van der Voort* - Enhanced neutrophil infiltration and distinct spatial patterning in non-draining lymph nodes under adoptive T cell therapy in murine melanoma (Tumor Microenvironment)
No. 87 Kilian Volmer - Modelling a potential spread of Foot-and-Mouth disease on the German animal trading networks (Infectious Disease Modelling)
No. 89 Karina Wallrafen-Sam - Wastewater-Informed Agent-Based Modeling of Hepatitis E Transmission Dynamics (Infectious Disease Modelling)
No. 91 Nils Waßmuth* - Comparison of Simulation-based Inference Methods for Stochastic Compartmental Models (Infectious Disease Modelling)
No. 93 Daniel Weindl - PEtab, pyPESTO, and AMICI: A Reproducible and Efficient Pipeline for Simulation and Parameter Estimation of Dynamic Models (Modelling of Cellular Pathways)
No. 95 Anna Wendler - Models based on integro-differential equations for epidemic outbreaks (Infectious Disease Modelling)
No. 97 Lennart Wicker - Mathematical Inference of T-cell Trafficking Dynamics from Single-Cell Snapshots (Single-Cell Analysis)
No. 99 Myrthe S. Willemsen - A multi-country comparison of the impact of a potential HIV cure on HIV transmission dynamics (Infectious Disease Modelling)
No. 101 Lin Wouters - Fitting faster: speeding up parameter fitting in stochastic simulators through variance reduction (Mathematical Biology)
No. 103 Irene Yeboah - Intercellular Communication in Plasmodium-infected Liver Tissues: A Spatial Transcriptomics Analyses (Bioinformatics and Biostatistics)
No. 105 Yixuan Zeng - Helminth-Induced Immune Training and Its Potential Impact on Tumor Progression (Tumor Microenvironment)
No. 107 Henrik Zunker - Graph Neural Network Surrogates to leverage Mechanistic Expert Knowledge towards Reliable and Immediate Pandemic Response (Infectious Disease Modelling)
from 17:00
Social event (Arithmeum, "Haus der Geschichte or Bonn city center)
8:30 - 9:00
Welcome coffee (Foyer)
9:00 - 10:30
Keynotes
Session chair: Kevin Thurley • Lecture hall 2
9:00 - 9:45
Christoph Zechner (Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy)
Advancement of dynamic pathway modelling towards clinical translation
9:45 - 10:30
Dominic Grün (Institute of Systems Immunology, University of Würzburg, Germany)
Decoding the cellular circuitry of organ tissues
10:30 - 11:00
Coffee break (Foyer)
11:00 - 12:30
Parallel tracks with invited and selected talks
Tumor Microenvironment 2
Session chair: Marieta Toma
Lecture hall 7
11:00 - 11:15Federica Eduati (Eindhoven University of Technology, The Netherlands)
- Integrating spatial imaging and intracellular signaling to model emergent tumor–T cell dynamics with multiscale agent-based models
11:15 - 11:30Paras Jain (Indian Institute of Science, Bangalore, India)
- Modeling Epithelial-Mesenchymal Plasticity: A Driver of Immune Evasion in Cancer
11:30 - 11:45
Prihantini Prihantini (AI-BioMedicine Research Group, IMCDS-BioMed Research Foundation, Indonesia)
- Mathematical Modeling of RNA Velocity Manifold Dynamics Identifies Immune–Metastatic State Transitions and Tertiary Lymphoid Structure Stability Landscapes in Hepatocellular Carcinoma
11:45 - 12:00
David Cicchetti (Radboud University, Nijmegen, The Netherlands)
- Creating Realistic and Controllable Synthetic Tumor Microenvironment Images Using Diffusion Models Conditioned on Simulation Images
12:00 -12:15
Qianci Yang (Max Planck Institute for Evolutionary Biology, Plön, Germany)
- Stochastic Evolution of Resistance in Acute Lymphoblastic Leukemia
12:15 -12:30
Alireza Dostmohammadi (Department of Bioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany)
- Spatially Resolved Transcriptomics Reveals Microenvironment-Driven Heterogeneity in Cutaneous T-Cell Lymphoma
Single-Cell Analysis 1
Session chair: Lisa Steinheuer
Lecture halls 5+6
11:00 - 11:30
Alexander Skupin (Integrative Cell Signalling, Luxembourg Centre for Systems Biomedicine (LCBS), University of Luxembourg)
Cell Fate Dynamics at Single-Cell Resolution Reveals Biological Mechanisms in Health and Disease
11:30 - 11:45
Yang Zhao (Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden)
- Spatially resolving B cell clonal dynamics in human and murine tissues
11:45 - 12:00
Nadine van de Brug (Computer Science, Vrije Universiteit Amsterdam, The Netherlands)
- Mapping cellular states over time using a hierarchical feature expectation maximization approach for Gaussian mixture modeling
12:00 - 12:15
Alexander Aivazidis (Genome Biology, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany)
- STORMI leverages CRISPR interventions, DNA sequence syntax and multi-lineage dynamics to infer the regulatory mechanisms governing cell state dynamics
12:15 - 12:30
Isabel Mensah (Department of Mathematics, Kwame Nkrumah University of Science and Technology, Ghana)
- WAVDeSc: A Wavelet Based Denoising Pipeline for single-cell RNA Sequencing Data Analysis
Mathematical Biology 3
Session chair: Kevin Thurley
Lecture halls 3+4
11:00 - 11:30
Luciano Marcon (Andalusian Center for Developmental Biology, Spain)
The Network Basis of Pattern Formation: A Topological Atlas of Multifunctional Turing Networks
11:30 - 12:00
Miri Adler (The Hebrew University of Jerusalem, The Alexander Silberman Institute of Life Science, Israel)
Introducing Hot and Cold Fibrosis: Insights from a Cell-Circuit Theory of Tissue Organization
12:00 - 12:15
Harshavardhan BV (IISc Mathematics Initiative, Indian Institute of Science, India)
- Emergent dynamics of cellular decision making in multi-node mutually repressive regulatory networks
12:15 - 12:30
Inge Wortel (Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands)
- Cooperative motility emerges in crowds of T cells but not neutrophils
12:30 - 13:45
Lunch (University canteen - CAMPO)
13:45 - 15:00
Special invited talks
Session chair: Jan Hasenauer • Lecture hall 2
13:45 - 14:10
Andreas Reichel (Bayer AG, R&D - Preclinical Development, Berlin, Germany)
Mechanistic PK/PD Modelling of Targeted Protein Degradation: Transforming the Discovery of a Novel Therapeutic Modality
14:10 - 14:35
Heinrich Huber (Boehringer Ingelheim RCV GmbH & Co KG, Division Drug Discovery Sciences, Vienna, Austria)
Translational Insights from Semi‑Mechanistic Modelling of Tumour Growth
14:35 - 15:00
Lorenzo Contento (Pumas-AI Inc.)
A Deep Dive into Generative Scientific Machine Learning
15:00 - 15:45
Plenary discussion
Mathematical life sciences in the age of LLMs and AI bots
Lecture hall 2
15:45 - 17:00
Poster session 2 (even numbers)
with coffee break (Foyer & seminar room 1-4)
No. 2 Carolina Alvarez Garavito - A Deep Learning Framework for Multi-Site Signal Peptide Cleavage Prediction (Bioinformatics and Biostatistics)
No. 4 Shubhi Ambast - scGNNPred: Explainable graph neural networks for scRNA-seq-based phenotype classification (Bioinformatics and Biostatistics)
No. 6 Jonas Arruda - Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments (Mathematical Biology)
No. 8 Rafael Arutjunjan - Robust Global Model Analysis via the Stochastic Profile Likelihood Approximation (Modelling of Cellular Pathways)
No. 10 Severin Bang - Beyond mechanistic modeling: bridging the gap from signaling to phenotypical readout (Modelling of Cellular Pathways)
No. 12 Florian Bartsch - Graph-Based Modeling of Spatial Organization in Developing and Tumor Tissues (Tumor Microenvironment)
No. 14 Amatus Beyer - Model-Based Design for Morphogen-Driven Spatial Patterns in Synthetic Biology (Mathematical Biology)
No. 16 Sina Dadmand - Deciphering the effect of (R)-2-hydroxyglutarate (2-HG) on the tumor microenvironment of IDH mutant gliomas (Bioinformatics and Biostatistics)
No. 18 Luke De Bretton-Gordon - Learning Density-Dependent Cell-Cycle Regulation with UDEs (Tumor Microenvironment)
No. 20 Domagoj Doresic - Efficient Integration of Binary Qualitative Data into ODE Model Estimation (Mathematical Biology)
No. 22 Suman Gare - Data-driven multi-scale modeling of the tumor micro-environment using interpretable machine learning (Tumor Microenvironment)
No. 24 Mohammadamin Ghasemi - Neural Stem Cells Reroute Metabolism Under SHH Stress in Parkinson’s (Bioinformatics and Biostatistics)
No. 26 Nakshatra Ghosh - Mathematical Modeling of EMT Pathways in Cancer Invasion Through PDEs (Tumor Microenvironment)
No. 28 Sina Glöckner - Multicellular modelling of canonical NF-kB signaling (Modelling of Cellular Pathways)
No. 30 Stephan Grein - Evaluating the Performance of Parallel Optimization Methods for Large-Scale Dynamic Models in Computational Systems Biology (Modelling of Cellular Pathways)
No. 32 Julia Hafenbrak - Understanding CAR-T cell dynamics and therapeutic outcome for diffuse large B-cell lymphoma using mathematical modelling (Modelling of Cellular Pathways)
No. 34 Paul Jonas Jost - Making One Measurement Count: Efficient Dynamic Inference in Label-Based Models (Mathematical Biology)
No. 36 Moritz Kappes - Finite Element Space-Time Total Generalized Variation Regularization with applications to transmembrane potentials in ECGI (Mathematical Biology)
No. 38 Tugberk Kaya - Tissue Microarray-Based Spatial Transcriptomics Defines TME in Cholangiocarcinoma (Tumor Microenvironment)
No. 40 Rosa Kreider - A data-integrated framework for modeling cellular interactions with semi-Markov dynamics (Mathematical Biology)
No. 42 Michelle Krogemann - Random Walks or Directed Paths? – Harvesting the Potential of 3D Modeling to Uncover the Impact of Ontogeny on Alveolar Macrophage Dynamics (Organoids and Stem Cell Biology)
No. 44 Nantia Leonidou* - NephrESA: Machine learning-informed mechanistic mathematical modelling to optimize anaemia treatment (Modelling of Cellular Pathways)
No. 46 Carolin Lindow - Transcriptome-structured population models for neural stem cells (Mathematical Biology)
No. 48 Madhuri Majumder - Design principles of interferon signaling in regulating cell-density-dependent behavior under Type 1 diabetes scenario (Modelling of Endocrine Systems)
No. 50 Perla Mallouk - Mathematical Modeling of Neuroblastoma Growth Based on Tumoroid data (Organoids and Stem Cell Biology)
No. 52 Simon Merkt - Segmentation Strategies for Spatial Transcriptomics in Murine Adipose Tissue (Bioinformatics and Biostatistics)
No. 54 Josua Michael - Identifiability Analysis of Foundational Cardiac Electrophysiology Models: The Noble Model (Mathematical Biology)
No. 56 Luise Nagel - A covariation-based framework to model proteome network dynamics and phenotypic heterogeneity in Candida albicans (Bioinformatics and Biostatistics)
No. 58 Specioza Nambooze - Regulation of Notch signalling dynamics by cis-binding and cell neighborhood relationships. (Modelling of Cellular Pathways)
No. 60 Antonio de Jesus Ortiz Gonzalez - Bayesian Framework for Joint Motion-Compensated 3D MRI Reconstruction (Mathematical Biology)
No. 62 Dilan Pathirana - Groundwork for open-source nonlinear mixed-effects modeling and quantitative systems pharmacology, with SBML and Petab (Bioinformatics and Biostatistics)
No. 64 Clemens Peiter - Modeling Vaccine-Induced Antibody Dynamics Using Nonlinear Mixed-Effects Models in Healthcare Workers (Bioinformatics and Biostatistics)
No. 66 Katrin Perez Anderson - Mapping Lesion Niches: How Microglia Adapt to Recurrent Demyelination (Single-Cell Analysis)
No. 68 Maren Philipps - Modelling the HPA axis: Mechanisms and individual variability in a human cohort (Modelling of Endocrine Systems)
No. 70 Lorena Pohl - Mathematical modelling of electroporation (Mathematical Biology)
No. 72 Moritz Richter - Prediction of Drug Response in Patient-derived Organoids using Large-Scale Mechanistic Models (Organoids and Stem Cell Biology)
No. 74 Thomas Rohde - BaCoN (Balanced Correlation Network) improves prediction of gene buffering (Bioinformatics and Biostatistics)
No. 76 Patience Aba Sakyi - Modelling pattern formation in spatially discrete systems (Modelling of Cellular Pathways)
No. 78 Ivan Savchuk* - Enhancing Clinical Immunology and Disease Diagnostics with Global Swarm Learning (Single-Cell Analysis)
No. 80 Jan Dennis Schering - Simulation-Based Inference of Realistic Intracellular Dynamics in Tissue-Scale CPMs through GPU Parallelization (Mathematical Biology)
No. 82 Joanna Schnorr - A mathematical framework for quantifying T cell expansion in acute and chronic regulatory contexts (Mathematical Biology)
No. 84 Koert Schreurs - Predicting T cell motility from a single image (Tumor Microenvironment)
No. 86 Lea Seep - Decoding Kupffer Cell Programming in Maternal Obesity-induced Fatty Liver via Integrated Multi-Omics and Functional Analysis (Bioinformatics and Biostatistics)
No. 88 Paul Sellentin - Visual Insights into Complex Dynamical Systems via Flux Sensitivity Analysis (Modelling of Cellular Pathways)
No. 90 Shenwei Shi - Embedding-Based Annotation Method in Adipose Tissue Spatial Metabolomics (Bioinformatics and Biostatistics)
No. 92 Priyotosh Sil* - Biologically meaningful regulatory logic enhances the convergence rate in Boolean networks and bushiness of their state transition graph (Mathematical Biology)
No. 94 Lisa Maria Steinheuer - Predicting Vedolizumab Response in IBD Patients Using a Multimodal Machine Learning Approach (Bioinformatics and Biostatistics)
No. 96 Madheshvaran Suresh - Understanding cross-regulation of type I IFN and TNF in innate immune cells using data-driven mathematical modelling (Single-Cell Analysis)
No. 98 Viviane Timmermann - Image-Based Quantification of Autophagosome Biogenesis (Single-Cell Analysis)
No. 100 Marc Vaisband - Uncertainty-Aware Diversity Quantification via the Chinese Restaurant Process (Mathematical Biology)
No. 102 Szilard Varga - Do metrics from ecology help to classify clonal immune dynamics from T cell receptor repertoire data? (Mathematical Biology)
No. 104 Frederik Wieder - Elementary Flux Mode Sampling in Genome Scale Metabolic Networks (Modelling of Cellular Pathways)
No. 106 Vincent Wieland - Mathematical Modeling of the Aryl Hydrocarbon Receptor Pathway (Modelling of Cellular Pathways)
No. 108 Thomas Zerjatke - The digital bone marrow niche – A spatio-temporal in silico model of haematopoietic (stem) cells in their bone marrow microenvironment (Mathematical Biology)
17:00 - 18:30
Parallel tracks with invited and selected talks
Modelling of Cellular Pathways 3
Session chair: Stefan Engblom
Lecture hall 7
17:00 - 17:30
Federico Bocci (Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University, Nijmegen, The Netherlands)
Navigating the attractor landscape of single cells
17:30 - 17:45
Paolo Odello (Netherlands Cancer Institute (NKI), Computational Cancer Biology Group, Amsterdam, The Netherlands)
- Dissecting the efficacy of Multiple Low Dose Efficacy via computational modelling of EGFR-MAPK inhibition
17:45 - 18:00
Jeanne Le Clézio (Centre national de la recherche scientifique (CNRS) & Université Côte d'Azur, Laboratoire de Physiomédecine Moléculaire (LP2M), France)
- Physical-Chemistry of Cell Physiology: a top-down, transdisciplinary approach from obvious biological statements to interwoven multiscale algebraic dynamical systems and the need for a tractable mathematical framework
18:00 - 18:15
Rune Höper (Statistical Physics of Evolution, University of Leipzig, Germany)
- A Manually-Curated Stoichiometric Core Model Of Liver Metabolism
18:15 - 18:30
Simon Beyer (Institute of Physics, University of Freiburg, Germany)
- Quantitative Modeling Reveals Feedback Control of T Cell Receptor Trafficking and Surface Homeostasis
Single-Cell Analysis 2
Session chair: Alexander Skupin
Lecture halls 5+6
17:00 - 17:30
Pawel Paszek (Institute of the Fundamental Technological Research - Polish Academy of Sciences, Warsaw, Poland)
Memory, noise and infection: single-cell insights into innate immunity
17:30 - 17:45
Stanislaus Stein (BioQuant, University of Heidelberg, Germany)
- Geometric Modeling of Developmental Velocities in Single-Cell Data
17:45 - 18:00
James Boyle (Mathematical Institute, University of Oxford, UK)
- Inferring Cell-Cell Dynamics from Cell Trajectory Data Using Deep Attention Networks, and the Mechanisms Underlying T Cell Behavioural Heterogeneity in the Response to Cancer
18:00 - 18:15
Clémence Fournié (MAP5 laboratory, Université Paris Cité, France)
- Cell Trajectory Inference based on Schrödinger problem and a mechanistic model of stochastic gene expression
18:15 - 18:30
Tim Stohn (Vrije Universiteit Amsterdam, The Netherlands)
- Detecting changes in protein-covariation in smooth cell-state changes
Mathematical Biology 4
Session chair: Juan Velázquez
Lecture halls 3+4
17:00 - 17:15
Jonas Braß (Institute for Computer Science and Department of Biology, Heinrich Heine University, Düsseldorf, Germany)
- Mechanistical modelling of C4 plants - hydraulics model
17:15 - 17:30
Kumaran Bala Kandan Viswanathan (Radboud University, Nijmegen, The Netherlands)
- Simulation-Driven Representation Learning for Cell Motility Data
17:30 - 17:45
Nils Becker (Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany)
- Inference from Phylogenetic Somatic Variant Trees
17:45 - 18:00
Jan Rombouts (Unit of Theoretical Chronobiology, Université Libre de Bruxelles, Belgium)
- Geometry, timescales and boundaries affect aggregation-based patterning in multicellular systems
18:00 - 18:15
Madhumita Mondal (Homi Bhabha National Institute (HBNI), The Institute of Mathematical Sciences (IMSc), India)
- Node persistence from topological data analysis reveals changes in brain functional connectivity
18:15 - 18:30
Adrien Jolly (Department of Medicine 2, Hematology/Oncology, Goethe University Frankfurt, Germany)
- Dynamical modeling-informed interpretation of Ki67 positivity
from 19:30
Conference dinner
8:30 - 9:00
Welcome coffee (Foyer)
9:00 - 10:30
Keynotes
Session chair: Elena Reckzeh • Lecture hall 2
9:00 - 9:45
Christina Leslie (Computational & Systems Biology, Memorial Sloan Kettering Cancer Center, New York, USA)
Decoding cell dynamics and spatial organization in immune responses and the tumor microenvironment
9:45 - 10:30
Jeroen van Zon (AMOLF, Department of Autonomous Matter, Amsterdam, The Netherlands)
AI-driven single-cell tracking of homeostasis in organoids
10:30 - 11:00
Coffee break (Foyer)
11:00 - 12:30
Parallel tracks with invited and selected talks
Bioinformatics and Biostatistics 2
Session chair: Lea Seep
Lecture hall 7
11:00 - 11:15
Laura Koebbe (Institute for Human Genetics, University Hospital Bonn, Germany)
- Rare functional variants in FBN2 are strong genetic determinants for bicuspid aortic valve disease
11:15 - 11:30
Cong Quan Ta (Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg & Department of Applied Computer Science and Medicine, University of Augsburg, Germany)
- Integration of proteomics data from cell lines and tumors to profile patient drug sensitivity
11:30 - 11:45
Lea Weber (Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany)
- Reconstructing Stem-Cell Population Dynamics from Somatic-Mutation Phylogenies in Ageing Mice
11:45 - 12:00
Diego Valderrama (Fraunhofer Institute for Algorithms and Scientific Computing SCAI, St. Augustin, Germany)
- MultiNSDEs: Dose-Guided Neural SDEs for Simulating Real and Counterfactual Patient Trajectories
12:00 - 12:15
Lotta Eriksson (Department of Mathematical Sciences, Chalmers University of Technology & University of Gothenburg, Sweden)
- Sensitive detection of copy number alterations in low-quality liquid biopsy sequencing data
12:15 - 12:30
Manuel Huth (Life & Medical Sciences Institute (LIMES) & Bonn Center for Mathematical Life Science, University of Bonn, Germany)
- NoLimits.jl: A flexible Julia framework for nonlinear and latent-state mixed-effects modeling
Organoids and Stem Cell Biology
Session chair: Elena Reckzeh
Lecture halls 5+6
11:00 - 11:15
Stefan Engblom (Department of Information Technology, Division of Scientific Computing, Uppsala University, Sweden)
- From single cells to tumors: computational modeling and analysis of cell populations
11:15 - 11:30
Millicent Afrifa Opoku (African Institute for Mathematical Sciences Ghana)
- Geometry-dependent FGF4-ERK signalling drives epiblast-primitive endoderm proportioning in a Cellular Potts model of the human blastocyst
11:30 - 11:45
Lutz Brusch (Center for Interdisciplinary Digital Sciences, Technische Universität Dresden, Germany)
- Virtual Embryo: Blastocyst and Organoid Models in the Morpheus Simulation Framework
11:45 - 12:00
Xuan Zheng (Hubrecht Institute, Utrecht, The Netherlands)
- Organoid cell fate dynamics in space and time
12:00 - 12:15
Ingmar Glauche (Institute for Medical Informatics and Biometry (IMB), TU Dresden, Germany)
- From data to dynamics: mechanistic models illuminate the clonal evolution of hematopoietic stem cells
12:15 - 12:30
Jasmitha Boovadira Poonacha (Life & Medical Sciences Institute (LIMES), University of Bonn, Germany)
- Influence of Culture Media Composition on Drug Sensitivity in CRC organoids
Mathematical Biology 5
Session chair: Nick Monk
Lecture halls 3+4
11:00 - 11:30
Stephen Moore (University of Cape Coast, Cape Coast, Ghana)
Retrospective Impact Quantification of Malaria Interventions in Ghana
11:30 - 11:45
Henrik Häggström (Department of Mathematical Sciences, Chalmers University of Technology & University of Gothenburg, Sweden)
- Simulation-based inference for stochastic nonlinear mixed-effects models with applications in systems biology
11:45 - 12:00
Mike van Santvoort (Department of Mathematics and Computer Science, Eindhoven University of Technology, The Netherlands)
- Modelling cell-cell interactions with random graphs
12:00 - 12:15
Gloria Agyeiwaa Botchway (Department of Mathematics, University of Ghana, Legon-Accra, Ghana)
- On a modified Leslie-Gower model with prey defense and predator cannibalism
12:15 - 12:30
Johannes Textor (Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands)
- What Does the Shape Space of T-Cell Epitopes Look Like?
12:30 - 13:00
Closing (Lecture hall 2)